Food clock San Francisco
-food in time you feel a little tired and sticky after the excesses of Christmas?fast food One reason may not be that large amounts of food and alcohol, but the interruption of "food clock" just internal organs.food clock.
That the human body is controlled by a clock food is generally well established. However, a recent study by researchers at the University of California, San Francisco (UCSF) has helped scientists understand how this clock at the molecular level.
The food of the biological food in time clock is a collection of interactions between genes and molecules known technically, if a little awkwardly food clock , as "food derivable" oscillator, which keeps the human body metabolism in fast food good shape. Clock Food is designed to help people make the most of our nutritional intake.
The impact on "food clock" felt by many revelers food in time Christmas is the same as that experienced by people who are jet-lag, and those working in food clock night shifts.
food clock Research, as shown in a report, it was shown that a protein called Pkwy is essential in the clock reset food if the change in eating habits. The study showed that normal laboratory mice that were fed during normal business hours of sleep clock adjust their food over time and begin to awaken from their lethargy food clock, and run forward to the new meal. However, mice lacking Pkwy gene are not able to respond to changes in their lunch instead of sleeping through it.
The work has implications for understanding the molecular basis of diabetes and obesity. This is because the food timing food clock clock can be used as part of the justification for these disorders.
The new research is published in the journal Proceedings of the National Academy of Sciences.
If the sin of eating excess system sends holiday slathered in butter, brandy soaked overload, you're not alone: unpeople who are jet-lag, the people who work night shifts and night snacks Old Course know exactly how to feel.
All these "food clock" boring activities, the body of a collection of interacting genes and known technically as food derivable oscillator that keeps the body on the same keel metabolic molecules. A new study by researchers at UCSF is a help reveal how the clock at the molecular level.
Published this month in the fast food journal Proceedings of the National Academy of Sciences, the UCSF team showed that a protein called Pkwy is essential in the clock reset food if our eating habits change.
The study showed that fast food normal laboratory mice that were fed during normal business hours of sleep clock adjust their food over time and begin to awaken from their food clock lethargy, and run forward to the new meal. food clock However, mice lacking Pkwy gene are not able to respond to the changing room - instead of sleeping through it.
The work has implications for understanding the molecular basis food clock of diabetes, obesity and other metabolic syndromes due food clock to supply clock sync can be used as part of the underlying pathology in these disorders has said Louis Tack,food clock MD, John C. Coleman Distinguished Professor of Neurology at UCSF and the Howard Hughes Medical Institute.
It can also help to explain why the food clock owls are more likely to be obese than early risers, Tack said.food clock
"Understanding the molecular mechanism of how to eat in the" wrong "time of day clocks in sync our bodies fast food can facilitate the development of better treatments for disorders associated with night eating syndrome, shift work and jet lag" at he added.
Power reset timer
Look behind the face of a mechanical clock and you will see an amazing array of gears, wheels, counterweight parts and other moving parts. Biological clocks are equally complex, consisting of several interacting genes that are activated or deactivated in an orchestration to keep time during the day.
In most organisms, biological clock mechanisms are governed by a master clock, known as the "circadian pacemaker" that keeps track of the time and coordinates biological processes with the rhythm of a cycle of 24 hours of day and night.
Life forms as diverse as humans, mice and mustard greens have all the time masters. And in the last decade, scientists have discovered several of its internal food clock mechanisms, discovering that many genes whose cycles are linked with the clock and the discovery of how mammals is controlled by a small stain in the brain known as the "core superheats. "
Scientists also know that in addition to the master clock, our bodies have other watches that run in parallel throughout the day.
One is the clock of the food, which is not tied to a food in time specific location in the brain, but several sites throughout the body.
The clock of the food is there to help our body to make the most of our nutritional intake. It controls the genes that help at all, the absorption of nutrients in the digestive tract to the dispersion through the bloodstream, and is designed to anticipate eating habits. Even before eating a meal, our body starts to turn in some of these genes on and off, preparing for the beginning of life - if we feel the pangs of hunger as lunchtime arrives.
Scientists know that the food clock can be reset over time if an organization changes their eating habits, overeating or during their free time,food clock as the clock of the food is related to the food during the main fast food source of food research and hunting for hours in the day. But so far, little is known about how the food clock at the genetic level.food in time
What Tack and his colleagues have discovered is food clock the molecular basis of this phenomenon Pkwy protein binds to another molecule food clock called Mal stabilized, moving the clock time.
The article "Pkwy is involved in driving food by Mal regulation" is written blowing Zhang, DIY Abraham, Shut-Ting Lin food clock, Henri Foster, Gregory Michele, Ying-Hi Fun and Louis J. Tack and appears in Proceedings of the National Academy of Sciences.
In addition to UCSF, the authors of food in time the study are affiliated with the Max Planck Institute for Biophysical Chemistry in Getting,food clock Germany.
This work was funded by the National Institutes of Health through grants GM # 708 and # HL Fund, the Sandler Eurocentric and Howard Hughes Medical Institute food clock.
